HORDB

ID: hor004577
Uniprot ID: Q8T697(2-44)
Protein name: Thymosin beta
Gene name: NA
Organism: Aplysia californica (California sea hare)
Family: Thymosin beta family
Source: animal
Expression: Expressed in regenerating axons.
Disease: NA
Comments: NA
Taxonomy: Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0003779 actin binding; GO:0003785 actin monomer binding
GO BP: GO:0007015 actin filament organization
GO CC: GO:0005737 cytoplasm; GO:0005856 cytoskeleton

Function: Plays an important role in the organization of the cytoskeleton. May be involved in the regulation of structural plasticity in the CNS.
Mechanism: Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004577_AF2.pdb

hor004577_ESM.pdb

Mass:	572885	Formula:	C215H354N60O75
Absent amino acids:	ACMRWY	Common amino acids:	K
pI:	7.7	Basic residues:	12
Polar residues:	10	Hydrophobic residues:	6
Hydrophobicity:	-182.33	Boman Index:	-15560
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	43.02
Instability Index:	2003.72	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 16924592
Title: Identification and Characterization of Homologues of Vertebrate Beta-Thymosin in the Marine Mollusk Aplysia Californica